ODCs

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1 OMIM reference -
1 associated gene
10 signs/symptoms

COMMON GENES: 1
COMMON SIGNS: 9

1 OMIM reference -
2 associated genes
16 signs/symptoms

Infantile-onset ascending hereditary spastic paralysis

Juvenile primary lateral sclerosis

ALS2	(UniProt - OMIM)		ALS2	(UniProt - OMIM)
			ERLIN2	(UniProt - OMIM)

Citations in the biomedical literature:

Infantile-onset ascending hereditary spastic paralysis		Juvenile primary lateral sclerosis
	Synonym(s): - IAHSP		Synonym(s): - JPLS - Juvenile PLS

	Classification (Orphanet): - Rare genetic disease - Rare neurologic disease		Classification (Orphanet): - Rare genetic disease - Rare neurologic disease

	Classification (ICD10): - Diseases of the nervous system -		Classification (ICD10): - Diseases of the nervous system -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: adult Type of inheritance: autosomal recessive		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: childhood Average age of death: any age Type of inheritance: autosomal recessive

	External references: 1 OMIM reference - No MeSH references		External references: 1 OMIM reference - 1 MeSH reference: C536416


COMMON SIGNS	- Autosomal recessive inheritance - Elocution disorders / dysarthria / dysphonia - Feeding disorder / dysphagia / swallowing / sucking disorder / esophageal dyskinesia - Hemiplegia / diplegia / hemiparesia / limb palsy - Hypereflexia - Hypertonia / spasticity / rigidity / stiffness - Pseudobulbar signs / spasmodic laugh and cry - Pyramidal syndrome - Speech troubles / aphasia / dysphasia / echolalia / mutism / logorrhea / dysprosodia

Infantile-onset ascending hereditary spastic paralysis		Juvenile primary lateral sclerosis
	Frequent - Abnormal eye movements / oculomotor disorder		Very frequent - Abnormal gait - Ataxia / incoordination / trouble of the equilibrium - Motor deficit / trouble - Muscle weakness / flaccidity Occasional - Bladder and ureter anomalies - Muscle hypotrophy / atrophy / dystrophy / agenesis / amyotrophy - Sensitive trouble / deficit